Berberine Benefits: What 46 Trials Show, Plus the Side Effects

TonicNest card in brand colour reading Berberine benefits, side effects and drug interactions, with capsule outlines in the background

Berberine benefits in trials are modest. A review of 46 studies found small drops in blood sugar and blood fats, mostly as an add-on to standard care, and weight fell about 2 kg or less. Side effects are mainly nausea, diarrhea and constipation. Berberine can raise cyclosporine levels, affect diabetes medicines, and should not be used in pregnancy, breastfeeding or infancy.

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Edited by Owen Hartley, Reviews Editor

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TonicNest is general information, not medical advice. Dietary supplements are not reviewed by the FDA for safety or effectiveness before they are sold. Talk to your doctor before you start, stop or combine supplements. Some links are affiliate links: if you buy through them we may earn a commission at no extra cost to you, and it never changes what we report.